Oncology

Date: 12 – 13 October 2023
Place: Bern
Language: English
Registration deadline single module: 28 September 2023

Goals of the module

Participants

  • have an overview on sex differences in oncology and the scientific, clinical and societal implications of sex differences for prevention, diagnosis and treatment of cancer.
  • are familiar with the combined impact of sexual hormones and sex chromosomes on cancer susceptibility with a focus on intrinsic control of cancer initiating cell populations, tumor microenvironment and systemic determinants of cancer development.
Content of the module
  • Rationale for considering sex and gender in cancer prevention and treatment
        • Sex differences in epidemiology of various cancers
        • Sex and gender differences in carcinogen exposition (UV light, smoking, environmental carcinogens)
  • Sex chromosomes and their impact on cancer susceptibility
      • Estrogens and their impact on cancer risk in females and males
      • Endocrine disruptors
      • Androgens and their impact on cancer risk in females and males
  • Impact of sex on systemic determinants of cancer development
    • immunity
    • tumor microenvironment
    • cancer initiating cells
    • metabolism
    • microbiome
    • Clinical implications of sex and gender differences in cancer
      • Sex differences in response and toxicity of anticancer therapies (cytotoxics, targeted therapies and immunotherapies)
      • Sex differences in oncological surgery and radiotherapy outcomes
      • Implications for clinical trial design and reporting of results
      • Sex-specific drug dosing strategies?
      • Sex-specific cancer prevention efforts?