Place: Bern
Language: English
Registration deadline single module: 1 week before module start
Fee: two-day module CHF 500, single-day booking CHF 280
Goals of the module
Participants
- have an overview on sex differences in oncology and the scientific, clinical and societal implications of sex differences for prevention, diagnosis and treatment of cancer.
- are familiar with the combined impact of sexual hormones and sex chromosomes on cancer susceptibility with a focus on intrinsic control of cancer initiating cell populations, tumor microenvironment and systemic determinants of cancer development.
Content of the module
- Rationale for considering sex and gender in cancer prevention and treatment
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- Sex differences in epidemiology of various cancers
- Sex and gender differences in carcinogen exposition (UV light, smoking, environmental carcinogens)
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- Sex chromosomes and their impact on cancer susceptibility
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- Estrogens and their impact on cancer risk in females and males
- Endocrine disruptors
- Androgens and their impact on cancer risk in females and males
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- Impact of sex on systemic determinants of cancer development
- immunity
- tumor microenvironment
- cancer initiating cells
- metabolism
- microbiome
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- Clinical implications of sex and gender differences in cancer
- Sex differences in response and toxicity of anticancer therapies (cytotoxics, targeted therapies and immunotherapies)
- Sex differences in oncological surgery and radiotherapy outcomes
- Implications for clinical trial design and reporting of results
- Sex-specific drug dosing strategies?
- Sex-specific cancer prevention efforts?
- Clinical implications of sex and gender differences in cancer